Barry B. Benson, voiced by Jerry Seinfeld, is an independent bee that doesn't like the prospect of being stuck in a single job for the rest of his life. The prospect of making the wrong choice sends him out of the career line and into the adventure of a lifetime.
His daring antics earn him a trip outside the hive with the "Pollen Jocks" where he gets lost and winds up almost getting crushed by a seriously over-reacting human, Ken. Vanessa Bloome (Renée Zellweger) saves his from this fate asking, "Why does his life have any less value than yours?"
Barry is so overcome with gratitude that he decides to violate the cardinal Bee Law (No talking to humans) in order to thank her. After Vanessa recovers from the incredible shock of encountering a talking bee they become friends. Since Vanessa is a florist this only adds to the attraction since they have a common interest: flowers.
One on of their outings together Barry is stunned to discover shelves full of bottle honey at the supermarket. Barry decides that this injustice must be righted an, with Vanessa's help, he sue the human race on behalf of all bees everywhere.
I'll leave the rest of the plot for the movie-goers, but I will say that I laughed a good deal more at the theatre while watching this film than I have for a while. There is a steady stream of bee-related jokes and cultural references for young and old alike. While some concepts are taken a little too far out of the realm of possibility, the overall message regarding the importance of bees in our world is both relevant and timely.